Dr. Akhilesh Gaharwar and Dr. Irtisha Singh meticulously describe the #bioengineered (malignant) lymphoid tissue, its need, novelty, impact, & well point to @US_FDA Modernization Act 2.0!

Gaharwar, A.K., Singh, I. A synthetic tumour microenvironment. Nature Materials. (2023). https://doi.org/10.1038/s41563-023-01511-6

Thrilled to share our work in @NatureMaterials on profiling lymphoid tumor microenvironment & engineering Lymphoma organoids to define complex cell-TME crosstalks! Huge congrats to Ph.D. @shivemshah & all collabs!! Thx @NIH @WellcomeLeap HOPE for your support!

S. B., Shah, C. Carlson, K. Lai, Z. Zhong, G. Marsico, K. Lee, N. Félix-Velez, E. Abeles, M. Allam, T. Hu, L. Walter, K. Martin, K. Gandhi, B. Butler, R. Puri, A. McCleary-Wheeler, W. Tam, E. Elemento, K. Takata, C. Steidl, D. Scott, L. Fontan, H. Ueno, B. Cosgrove, G. Inghirami, A. J. García, A. Coskun, J. L. Koff, A. Melnick, A. Singh*. Combinatorial Targeting of Aberrant Signaling Pathways in Lymphomas Rescues Lymphoid Tumor Microenvironment-mediated attenuation of MALT1 inhibitors. Nature Materials, 2023, https://doi.org/10.1038/s41563-023-01495-3.